Dosage and Administration

Patients should be trained in proper administration techniques, including dosing frequency, ampule dispensing, the
I-neb^® Adaptive Aerosol Delivery (AAD^®) System, and equipment cleaning.

• I-neb training and support are available from the specialty pharmacy in home or at the office
• 6 to 9 inhalations daily during waking hours
• No more than once every 2 hours
• In the pivotal trial 90% of patients did not take treatments at night¹
• Initial dose: 2.5 mcg (10 mcg/mL)
• If well tolerated, increase to 5 mcg (10 mcg/mL) and maintain; otherwise, reduce to 2.5 mcg
• For patients maintained at 5 mcg who have repeatedly experienced extended treatment times which could result in incomplete dosing (standard treatment time is 4 to 10 minutes), consider transitioning to 20 mcg/mL
• Vital signs must be monitored while initiating VENTAVIS^® (iloprost) Inhalation Solution
• VENTAVIS is an inhaled therapy with no catheter-related issues
• Discard any solution remaining in the medication chamber after each inhalation session
• Do not mix VENTAVIS with other medications

^†Different colored chambers and dosing discs are NOT interchangeable. Patients should not use the 20 mcg/mL ampule with the purple- or red-latched medication chambers.

Breath-actuated precision dosing

The I-neb generates micro-aerosol and analyzes breathing patterns, delivering drug during only the first 80% of inhalation to maximize lung deposition.^2,16

Based on in-vitro study
Adapted from Nikander¹⁶

The I-neb AAD System was designed to analyze breathing patterns. It determines the starting point for aerosol delivery by measuring the pressure changes in airflow,² and then sets the duration of each pulse by analyzing the particular breathing pattern.¹⁶ The I-neb continually adapts aerosol delivery to changes in breathing patterns.²

Tidal volume and inspiration/expiration ratios of conventional nebulizers and the I-neb AAD²

Adapted from Denyer²

Faster treatment times for patient compliance^‡

In vitro studies showed that the higher 20 mcg/mL concentration shortens treatment times for appropriate patients^‡§

• Higher concentration
• 50% reduction in inhaled volume
• 62% mean reduction in delivery time (5 mcg dose) based on an in vitro study¹⁴
• Shorter treatment times^‡
• Helps maintain patient compliance

^‡The 20 mcg/mL concentration is intended for patients who are maintained at the 5 mcg dose and who have repeatedly experienced extended treatment times which could result in incomplete dosing. VENTAVIS 10 mcg/mL ampules are still available. VENTAVIS should be taken 6 to 9 times daily, at least 2 hours apart.¹

^§Based on an in vitro study with a manually generated 28.3-L/min, 15-sec inhalation cycle breathing pattern.¹⁴